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Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study.

Matthew T RätsepA PaolozzaA F HickmanB MaserVanessa R KayShuhiba MohammadJessica PudwellGraeme N SmithDonald C BrienPatrick W StromanMichael A AdamsJames N ReynoldsB Anne CroyNils Daniel Forkert
Published in: AJNR. American journal of neuroradiology (2015)
This study is the first to report brain structural and vascular anatomic alterations in the population of offspring of pre-eclamptic pregnancies. Brain structural alterations shared similarities with those seen in autism. Vascular alterations may have preceded these structural alterations. This pilot study requires further validation with a larger population to provide stronger estimates of brain structural and vascular outcomes among the offspring of pre-eclamptic pregnancies.
Keyphrases
  • resting state
  • white matter
  • high fat diet
  • functional connectivity
  • preterm birth
  • cerebral ischemia
  • gestational age
  • pregnancy outcomes
  • autism spectrum disorder
  • blood brain barrier
  • subarachnoid hemorrhage