Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons.

Shanshan LinAiguo RenLinlin WangChloe SantosYun HuangLei JinZhiwen LiNicholas D E Greene

Published in: Clinical epigenetics (2019)

Hypermethylation of Pax3 may play a role in the development of NTDs; DNA methylation aberration may be caused by exposure to BaP, with possible involvement of oxidative stress.

Keyphrases

polycyclic aromatic hydrocarbons
dna methylation
genome wide
oxidative stress
copy number
gene expression
dna damage
ischemia reperfusion injury
diabetic rats
genome wide identification