Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan).
Hiroko NatsumeKinga SzczepaniakHidetaka YamadaYuji IwashitaMarta GędekJelena ŠutoKeiko IshinoRika KasajimaTomonari MatsudaFelix ManirakizaAugustin NzitakeraYijia WuNong XiaoQiong HeWenwen GuoZhenming CaiTsutomu OhtaTıberiu SzekelyZoltan KadarAkiko SekiyamaTakashi OshimaTakaki YoshikawaAkira TsuburayaNobuhito KuronoYaping WangYohei MiyagiSimona GurzuHaruhiko SugimuraPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2023)
The divergence in mutation spectrum of GC in different areas in the world may reflect various pathogeneses and etiologies of GC, region to region. Diversified mutation spectrum in GC in Eastern Europe may suggest GC in Europe has different carcinogenic pathway of those from Asia.