Sensitivity of T1/T2-weighted ratio in detection of cortical demyelination is similar to magnetization transfer ratio using post-mortem MRI.
Yufan ZhengJessica DudmanJacqueline T ChenKedar R MahajanDanielle HermanRobert J FoxDaniel OntanedaBruce D TrappKunio NakamuraPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
Although somewhat sensitive, the modest specificity of conventional MRI modalities for cortical demyelination indicates that they are influenced by cortical changes other than demyelination. Improved acquisition and post-processing are needed to reliably measure cortical lesion load.