Clinico-genomic profiling of conventional and dedifferentiated chondrosarcomas reveals TP53 mutation to be associated with worse outcomes.

Ryan A Denu Richard K Yang Alexander J F Lazar Shalin S Patel Valerae O Lewis Jason Roszik Jonathan A Livingston Wei-Lien Wang Kenna Rael Shaw Ravin Ratan Maria Alejandra Zarzour Justin E Bird Shaan M Raza Kadir C Akdemir Jordi Rodon Ahnert Vivek Subbiah Shreyaskumar R Patel Anthony P Conley

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

IDH mutations are prevalent in chondrosarcoma though were not associated with survival outcomes in this cohort. TP53 mutations were the next most common alteration and were associated with worse outcomes.

Keyphrases

low grade
single cell
copy number
metabolic syndrome