Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model.

Thomas C ChenWinston H WuKi-Eun ChangAxel H SchönthalEli S GangVic IndravudhThomas LoblFrank AdellYehoshua Shachar

Published in: Neurosurgery (2024)

This implantable pump system enables external control of drug output, so that the resulting intraventricular drug concentrations can continuously be maintained within the therapeutic range.

Keyphrases

drug delivery
white matter
adverse drug
drug induced
resting state