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Pharmaceutical Residues in Edible Oysters along the Coasts of the East and South China Seas and Associated Health Risks to Humans and Wildlife.

Rongben WuYan Yin SinLin CaiYouji WangMenghong HuXiaoshou LiuWenzhe XuKit Yue KwanDavid GonçalvesBenny Kwok Kan ChanKai ZhangApple Pui-Yi ChuiSong Lin ChuaJames Kar-Hei FangKenneth Mei-Yee Leung
Published in: Environmental science & technology (2024)
The investigation of pharmaceuticals as emerging contaminants in marine biota has been insufficient. In this study, we examined the presence of 51 pharmaceuticals in edible oysters along the coasts of the East and South China Seas. Only nine pharmaceuticals were detected. The mean concentrations of all measured pharmaceuticals in oysters per site ranged from 0.804 to 15.1 ng g -1 of dry weight, with antihistamines being the most common. Brompheniramine and promethazine were identified in biota samples for the first time. Although no significant health risks to humans were identified through consumption of oysters, 100-1000 times higher health risks were observed for wildlife like water birds, seasnails, and starfishes. Specifically, sea snails that primarily feed on oysters were found to be at risk of exposure to ciprofloxacin, brompheniramine, and promethazine. These high risks could be attributed to the monotonous diet habits and relatively limited food sources of these organisms. Furthermore, taking chirality into consideration, chlorpheniramine in the oysters was enriched by the S -enantiomer, with a relative potency 1.1-1.3 times higher when chlorpheniramine was considered as a racemate. Overall, this study highlights the prevalence of antihistamines in seafood and underscores the importance of studying enantioselectivities of pharmaceuticals in health risk assessments.
Keyphrases
  • health risk
  • drinking water
  • physical activity
  • risk factors
  • body mass index
  • heavy metals
  • cystic fibrosis
  • multidrug resistant
  • climate change
  • gram negative