Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1.
Umaiyal KugathasanMatthew R B EvansJasper M MorrowChristopher D J SinclairJohn S ThorntonTarek A YousryThorsten HornemannSaranya SuriyanarayananKhadijah Owusu-AnsahGiuseppe LauriaRaffaella LombardiJames M PolkeEmma WilsonDavid L H BennettHenry HouldenMichael G HannaJulian C BlakeMatilde LauraAlexander Martin RossorPublished in: Journal of neurology, neurosurgery, and psychiatry (2019)
MRI determined calf muscle fat fraction shows validity and high responsiveness over 12 months and will be useful in HSN1 clinical trials.