Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.
Anupama TiwariJongyun MyeongArsalan HashemiaghdamHao ZhangXianfeng NiuMarissa A LaramieMarion I StunaultJasmin SponagelGary J PattiLeah P ShriverVitaly A KlyachkoGhazaleh AshrafiPublished in: bioRxiv : the preprint server for biology (2024)
Serum pyruvate is taken up by the brain and efficiently oxidized in the TCA cycle.The mitochondrial pyruvate carrier (MPC) is essential for presynaptic energy metabolism.Acetylation of the MPC complex modulates mitochondrial pyruvate uptake.MPC activity regulates the release and retrieval of synaptic vesicles in nerve terminals.