Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats.

Ayed A Dera Prasanna RajagopalanMohammad A AlfhiliIrfan AhmedHarish C Chandramoorthy

Published in: BioFactors (Oxford, England) (2019)

In summary, Tq exhibited protective effects on hyperuricemia-mediated renal oxidative stress and mitochondrial abnormalities which could be mediated by Nrf2/HO-1, Akt signaling pathways.

Keyphrases

oxidative stress
signaling pathway
induced apoptosis
dna damage
diabetic rats
ischemia reperfusion injury
uric acid
pi k akt
cell proliferation
cell death
epithelial mesenchymal transition
reactive oxygen species
endoplasmic reticulum stress