Recombinant irisin enhances the extracellular matrix formation, remodeling potential, and differentiation of human periodontal ligament cells cultured in 3D.

Yang YangTianxiang GengAthina Samara Ole Kristoffer Olstad Jianying He Anne Eriksson Agger Bjørn Helge Skallerud Maria A Landin Catherine Anne Heyward Helen Pullisaar Janne Elin Reseland

Published in: Journal of periodontal research (2023)

Irisin altered the morphology in primary hPDL cell-derived spheroids, enhanced its ECM deposition, mechanical properties, differentiation and remodeling potential.

Keyphrases

extracellular matrix
endothelial cells
induced apoptosis
cell cycle arrest
human health
risk assessment
cell proliferation