pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy.

Lei XingJin-Yuan LyuYue YangPeng-Fei CuiLiu-Qing GuJian-Bin QiaoYu-Jing HeTian-Qi ZhangMinjie SunJin-Jian LuXiaojun XuYu LiuHu-Lin Jiang

Published in: Chemical communications (Cambridge, England) (2017)

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.

Keyphrases

cancer therapy
drug delivery
oxide nanoparticles
cell death
reactive oxygen species
endoplasmic reticulum
single cell
walled carbon nanotubes