Optimization of an Allysine-Targeted PET Probe for Quantifying Fibrogenesis in a Mouse Model of Pulmonary Fibrosis.
Sergey ShuvaevRachel S KnipeMatt DrummondNicholas J RotileIlknur AyJonah P Weigand-WhittierHua MaIris Yuwen ZhouJesse D RobertsKatherine BlackLida P HaririYingying NingPeter CaravanPublished in: Molecular imaging and biology (2023)
GaPIF-7, exhibited the highest uptake in fibrogenic lung, low uptake in surrounding liver or heart tissue, and low lung uptake in healthy mice and should be considered for further clinical translation.