Design of an Ara h 2 hypoallergen from conformational epitopes.
Jungki MinTarun KeswaniNicole A LaHoodIsabelle R LytleOrlee Marini-RapoportLéna AndrieuxSunny L SneedLori L EdwardsRobert M PetrovichLalith PereraAnna PomésLars C PedersenSarita U PatilGeoffrey A MuellerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
These studies demonstrate that prior knowledge of common conformational epitopes can be used to engineer reduced IgE reactivity, an important first step in hypoallergen design.