Unraveling the Genomic-Epigenomic Interaction Landscape in Triple Negative and Non-Triple Negative Breast Cancer.

Jiande Wu Tarun Karthik Kumar MamidiLu ZhangChindo Hicks

Published in: Cancers (2020)

The investigation revealed integrated genomic, epigenomic and gene expression signatures and signing pathways unique to TNBC and non-TNBC, and a gene signature distinguishing the two types of breast cancer. The study demonstrates that integrative analysis of multi-omics data is a powerful approach for unravelling the genomic-epigenomic interaction landscape in TNBC and non-TNBC.

Keyphrases

copy number
single cell
gene expression
genome wide
dna methylation
young adults
deep learning
data analysis