Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles.

Christopher T RhodesDhanya AsokumarMira SohnShovan NaskarLielle ElishaParker StevensonDongjin R LeeYajun ZhangPedro P RochaRyan K DaleSoohyun LeeTimothy J Petros

Published in: Frontiers in cellular neuroscience (2024)

Thus, loss of Ezh2 in the MGE alters interneuron fate, morphology, and gene expression and regulation. These findings have important implications for both normal development and potentially in disease etiologies.

Keyphrases

gene expression
long noncoding rna
long non coding rna
dna methylation
single cell
genome wide
cell therapy