Rab32 facilitates Schwann cell pyroptosis in rats following peripheral nerve injury by elevating ROS levels.

Jiayi WangPin ChenGuanjie HanYongjie ZhouXingdong XiangMengxuan BianLei HuangXiang WangBinfeng HeShunyi Lu

Published in: Journal of translational medicine (2024)

Rab32 exacerbated Schwann cell pyroptosis in PNI model, leading to delayed peripheral nerve regeneration. Rab32 can be a potential target for future therapeutic strategy in the treatment of peripheral nerve injuries.

Keyphrases

peripheral nerve
single cell
cell therapy
stem cells
nlrp inflammasome
dna damage
cell death
oxidative stress
mesenchymal stem cells
human health
climate change