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Recent advances in the synthesis of carbazoles from indoles.

Trapti Aggarwalnull SushmitaAkhilesh K Verma
Published in: Organic & biomolecular chemistry (2019)
Carbazoles are privileged nitrogen heterocycles that are present in a wide range of natural products, pharmaceuticals, and functional materials. Due to their wide application, various synthetic strategies are available in the literature using substituted amines or indoles as a substrate. Thus, this review comprehensively highlights the (2015-2019) article that focuses on the synthesis of carbazoles derived from an indole-template through transition-metal catalyzed C-H functionalization, metal-free cyclization, three-component reaction, and electrophilic iodocyclizations. The synthetic strategies described in this review provided diversely substituted carbazoles and few of them have profound pharmacological activity.
Keyphrases
  • transition metal
  • molecular docking
  • systematic review
  • intellectual disability
  • room temperature
  • mass spectrometry
  • high resolution