Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia.
Yijia FangmaHaitong WanChongyu ShaoLiang JinYu HePublished in: Cellular and molecular neurobiology (2022)
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD + ) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated. This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- oxidative stress
- ischemia reperfusion injury
- signaling pathway
- endothelial cells
- histone deacetylase
- spinal cord
- induced apoptosis
- cell proliferation
- spinal cord injury
- pi k akt
- climate change
- multiple sclerosis
- white matter
- functional connectivity
- neuropathic pain