Pyroptosis activates conventional type I dendritic cells to mediate the priming of highly functional anticancer T cells.
Jordon M InkolMichael J WesterveldShayla G VerburgScott R WalshJodi MorrisonKaren L MossmanSarah M WorfolkKaslyn Lf KallioNoah J PhippenRebecca BurchettYonghong WanJonathan L BramsonSamuel Tekeste WorkenhePublished in: Journal for immunotherapy of cancer (2024)
Our study highlights that distinct types of cell death yield varying immunotherapeutic effect and selective activation of pyroptosis can be used to potentiate multiple aspects of the anticancer immunity cycle.