MicroRNAs overexpressed in Crohn's disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn's disease pathogenesis.
Cecilia Fernández-PonceRoberto Navarro QuirozAnderson Díaz PerezGustavo Aroca MartinezAndrés Cadena BonfantiAntonio Acosta HoyosLorena Gómez EscorciaSandra Hernández AgudeloChristian Orozco SánchezJosé Villarreal CamachoLinda Atencio IbarraJose Consuegra MachadoAlberto Espinoza GaravitoFrancisco García-CózarElkin Navarro QuirozPublished in: Clinical epigenetics (2021)
The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD.