Extracutaneous Melanotic Melanoma with Nervous System Involvement in a Buffalo ( Bubalus bubalis ).
José Diomedes BarbosaMariana Correia OliveiraCarlos Magno Chaves OliveiraHenrique Dos Anjos BomjardimTatiane Teles Albernaz FerreiraMarcos Dutra DuarteJosé Alcides Sarmento da SilveiraNatália da Silva E Silva SilveiraCamila Cordeiro BarbosaAluízio Otávio Almeida da SilvaAnibal Guillermo Armien MedianeroMarilene de Farias BritoPublished in: Veterinary sciences (2023)
Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.
Keyphrases
- spinal cord
- neuropathic pain
- induced apoptosis
- spinal cord injury
- stem cells
- skin cancer
- cell cycle arrest
- transcription factor
- cerebral ischemia
- resting state
- single cell
- magnetic resonance
- computed tomography
- signaling pathway
- cell death
- bioinformatics analysis
- brain injury
- functional connectivity
- contrast enhanced ultrasound