Characterization of forced degradation products of canagliflozine by liquid chromatography/quadrupole time-of-flight tandem mass spectrometry and in silico toxicity predictions.
Shandilya Mahamuni BairaPradipbhai D KalariyaRakesh NimbalkarPrabha GargR SrinivasM V N Kumar TalluriPublished in: Rapid communications in mass spectrometry : RCM (2018)
The drug was labile under oxidative stress condition. CAN reacted with co-solvent under acid hydrolytic conditions and gave pseudo-DPs. All the DPs were separated using UPLC and characterized by LC/QTOF/MS/MS. Toxicity of DPs was evaluated using TOPKAT and DEREK software tools.
Keyphrases
- tandem mass spectrometry
- liquid chromatography
- simultaneous determination
- oxidative stress
- ultra high performance liquid chromatography
- ms ms
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- mass spectrometry
- high resolution mass spectrometry
- gas chromatography
- solid phase extraction
- high resolution
- dna damage
- diabetic rats
- ischemia reperfusion injury
- heat shock
- ionic liquid
- oxide nanoparticles
- signaling pathway