Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study.
Monica AasLuis AlamedaMarta Di FortiDiego QuattronePaola DazzanAntonella TrottaLaura FerraroVictoria RodriguezEvangelos VassosPak ShamGiada TripoliCaterina La CasciaDaniele La BarberaIlaria TarriconeRoberto MuratoriDomenico BerardiAntonio LasalviaSarah TosatoAndrei SzökePierre-Michel LlorcaCelso ArangoAndrea TortelliLieuwe de HaanEva VelthorstJulio BobesMiguel BernardoJulio SanjuánJose Luis SantosManuel ArrojoCristina Marta Del-BenPaulo Rossi MenezesJean-Paul SeltenPeter B JonesHannah E JongsmaJames B KirkbrideBart P F RuttenJim van OsCharlotte Gayer-AndersonRobin M MurrayCraig MorganPublished in: Psychological medicine (2021)
Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates.