Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients.

Adrienne E BorrieFinnley A RoseYun-Hee ChoiFrancisco E PereraNancy ReadTracy SextonMichael LockTheodore A VandenbergKarin HahnJawaid YounusDiane LoganKylea PotvinBrian YaremkoEdward YuJohn LenehanStephen WelchWendy A TeftRichard B Kim

Published in: Breast cancer research and treatment (2020)

Our results suggested that BMI and AI drug (letrozole versus anastrozole) were clinical predictors of arthralgia, while genetic variants rs4775936, rs9322336, rs2234693, and rs9340799 were genetic predictors of AI-induced arthralgia. Significantly, rs4775936 was also a predictor of discontinuation of therapy.

Keyphrases

artificial intelligence
body mass index
polycystic ovary syndrome
genome wide
type diabetes
copy number
emergency department
gene expression
physical activity
machine learning
bone marrow
deep learning
cell therapy
replacement therapy
electronic health record