Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease.

David BäckströmM Eriksson DomellöfG GranåsenJ LinderS MayansE ElghH ZetterbergK BlennowL Forsgren

Published in: Acta neurologica Scandinavica (2017)

The results favor the hypothesis that dopamine deficiency in PD not only relate to mild cognitive deficits in frontostriatal functions, but also to a decline in memory and attention. This could indicate that dopamine deficiency impairs a wide network of brain areas.

Keyphrases

cognitive decline
uric acid
mild cognitive impairment
working memory
prefrontal cortex
replacement therapy
genome wide
metabolic syndrome
resting state
white matter
gene expression
dna methylation
functional connectivity
genome wide identification
bioinformatics analysis
network analysis
blood brain barrier