Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Leslie A Sandusky-BeltranAndrii KovalenkoChao MaJohn Ivan T CalahatianDevon S PlacidesMallory D WatlerJerry B HuntApril L DarlingJeremy D BakerLaura J BlairMackenzie D MartinSarah N FontaineChad A DickeyApril L LussierEdwin J WeeberMaj-Linda B SelenicaKevin R NashMarcia N GordonDave MorganDaniel C LeePublished in: Alzheimer's research & therapy (2019)
These data represent a novel paradigm linking tau pathology and polyamine dysfunction and that targeting specific arms within the polyamine pathway may serve as new targets to mitigate certain components of the tau phenotype.