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Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.

Leslie A Sandusky-BeltranAndrii KovalenkoChao MaJohn Ivan T CalahatianDevon S PlacidesMallory D WatlerJerry B HuntApril L DarlingJeremy D BakerLaura J BlairMackenzie D MartinSarah N FontaineChad A DickeyApril L LussierEdwin J WeeberMaj-Linda B SelenicaKevin R NashMarcia N GordonDave MorganDaniel C Lee
Published in: Alzheimer's research & therapy (2019)
These data represent a novel paradigm linking tau pathology and polyamine dysfunction and that targeting specific arms within the polyamine pathway may serve as new targets to mitigate certain components of the tau phenotype.
Keyphrases
  • cerebrospinal fluid
  • high glucose
  • diabetic rats
  • oxidative stress
  • electronic health record
  • cancer therapy
  • drug induced
  • endothelial cells
  • machine learning
  • drug delivery