Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study.

John T O'BrienMichael J FirbankKaren RitchieKatie WellsGuy B WilliamsCraig W RitchieLi Su

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

Our results show that progressive brain atrophy is associated with increased risk of future dementia in asymptomatic middle-aged subjects, two decades before dementia onset.

Keyphrases

mild cognitive impairment
cognitive impairment
risk factors
middle aged
white matter
resting state
multiple sclerosis
functional connectivity
current status
blood brain barrier