Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus.
Roberta Tancredi Francesco Dos SantosMarcelo Florencio Passos SilvaRafael Marques PortoIvo LebrunLuís Roberto de Camargo GonçalvesIsabel de Fátima Correia BatistaMaria Regina Lopes SandovalFernando Maurício Francis AbdallaPublished in: The journal of venomous animals and toxins including tropical diseases (2020)
The results of the present work show, for the first time, that muscarinic receptors are also affected by the Mlx-8 toxin, a muscarinic ligand with phospholipase A2 characteristics, obtained from the venom of the Elapidae snake Micrurus lemniscatus, since this toxin was able to compete with muscarinic ligand [3H]QNB in hippocampus of rats. In addition, Mlx-8 also blocked the accumulation of total [3H]inositol phosphate induced by muscarinic agonist carbachol. Thus, Mlx-8 may be a new pharmacological tool for examining muscarinic cholinergic function.