STAT3 enhances the constitutive activity of AGC kinases in melanoma by transactivating PDK1.

María Elisa PiccoMaría Victoria CastroMaría Josefina QuezadaGastón BarberoMaría Belén VillanuevaNatalia Brenda FernándezHyungsoo KimPablo Lopez-Bergami

Published in: Cell & bioscience (2019)

We show that PDK1 is a transcriptional target of STAT3, linking STAT3 pathway with AGC kinases activity in melanoma. These data provide further rationale for the ongoing effort to therapeutically target STAT3 and PDK1 in melanoma and, possibly, other malignancies.

Keyphrases

cell proliferation
gene expression
electronic health record
basal cell carcinoma
big data
deep learning
artificial intelligence
data analysis