A novel method of sacral nerve stimulation for colonic inflammation.
Ni Na ZhangHan ZhangLiu Qin JiangShengai ZhangJieyun YinLawrence SchrammPankaj P PasrichaJiande D Z ChenPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Both SNS-1h and SNS-3h significantly ameliorated intestinal inflammation; SNS-1h was superior to SNS-3h. Bipolar but not bilateral or unipolar stimulation improved the inflammation in colitis. SNS with 5 Hz intermittent stimulation but not the 14 Hz continuous SNS was better for treating colitis in rats. SNS with the optimized stimulation parameters increased vagal activity and decreased sympathetic activity. CONCLUSION & INFERENCES: Bipolar stimulation for 1 hour daily using intermittent 5 Hz parameters is most effective in improving colonic inflammation in TNBS-treated rats by inhibiting pro-inflammatory cytokines and increasing anti-inflammatory cytokines via the modulation of the autonomic function.