Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections.
Jelmer H van PuffelenBoris NovakovicLiesbeth van EmstDenise KooperTahlita C M ZuiverloonUrsula T H OldenhofJ Alfred WitjesTessel E GaleslootAlina VrielingKatja K H AbenLambertus A L M KiemeneyEgbert OosterwijkMihai G NeteaJoost L BoormansAntoine G van der HeijdenLeo A B JoostenSita H VermeulenPublished in: Journal for immunotherapy of cancer (2023)
We conclude that BCG immunotherapy induces trained immunity in NMIBC patients and this may account for the protective effects against respiratory infections. The data of our gene-based association analysis suggest that a link between trained immunity and oncological outcome may exist. Future studies should further investigate how trained immunity affects the antitumor immune responses in BCG-treated NMIBC patients.
Keyphrases
- muscle invasive bladder cancer
- end stage renal disease
- newly diagnosed
- immune response
- chronic kidney disease
- ejection fraction
- resistance training
- peritoneal dialysis
- prognostic factors
- prostate cancer
- genome wide
- dendritic cells
- transcription factor
- body composition
- rectal cancer
- patient reported outcomes
- current status
- genome wide analysis