Evaluation of Z-VAD-FMK as an anti-apoptotic drug to prevent granulosa cell apoptosis and follicular death after human ovarian tissue transplantation.
Maïté FransoletLaure NoëlLaurie HenrySoraya LabiedSilvia BlacherMichelle NisolleCarine MunautPublished in: Journal of assisted reproduction and genetics (2018)
In situ administration of Z-VAD-FMK slightly improves primary follicular preservation and reduces global apoptosis after 3 weeks of transplantation. Data presented herein will help to guide further researches towards a combined approach targeting multiple cell death pathways, angiogenesis stimulation, and follicular recruitment inhibition.
Keyphrases
- cell death
- endothelial cells
- cell cycle arrest
- oxidative stress
- cell proliferation
- electronic health record
- endoplasmic reticulum stress
- cancer therapy
- vascular endothelial growth factor
- induced pluripotent stem cells
- type diabetes
- emergency department
- metabolic syndrome
- skeletal muscle
- adipose tissue
- drug induced
- data analysis
- deep learning