Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11 C]UCB-J positron emission tomography study.
Sjoerd J FinnemaTakuya ToyonagaKamil DetynieckiMing-Kai ChenMark DiasQianyu WangShu-Fei LinMika NaganawaJean-Dominique GallezotYihuan LuNabeel B NabulsiYiyun HuangDennis D SpencerRichard E CarsonPublished in: Epilepsia (2020)
[11 C]UCB-J binding is reduced in the seizure onset zone of TLE subjects with MTS. PET imaging of SV2A may be a promising biomarker approach in the presurgical selection and evaluation of TLE patients and may improve the sensitivity of molecular imaging for seizure focus detection.