Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies.
Iago Pinal-FernandezJose Cesar MilisendaKatherine PakSandra Muñoz-BracerasMaria Casal-DominguezJiram Torres-RuizStefania Dell'OrsoFaiza NazGustavo Gutierrez-CruzYaiza Duque-JaimezAna Matas-GarciaJoan PadrosaFrancesc J Garcia-GarciaMariona Guitart-MampelGloria GarrabouErnesto Trallero-AraguásBrian WalittJulie J PaikJemima AlbaydaLisa Christopher-StineThomas E LloydJosep Maria Grau-JunyentAlbert Selva O'CallaghanAndrew Lee MammenPublished in: Annals of the rheumatic diseases (2023)
Based on these findings, we hypothesise that anti-Mi2 autoantibodies could exert a pathogenic effect by entering damaged myofibres, inhibiting the CHD4/NuRD complex, and subsequently derepressing the unique set of genes defined in this study.