Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer.

Samir GuptaBalambal BhartiDennis J AhnenDaniel D BuchananIona C ChengMichelle CotterchioJane C FigueiredoSteven J GallingerRobert W HaileMark A JenkinsNoralane M LindorFinlay A MacraeLoïc Le MarchandPolly A NewcombStephen N ThibodeauAung Ko WinMaría Elena Martínez

Published in: Cancer (2020)

Of CRC cases aged 40 to 49 years, 1 in 4 met family history-based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history-based guidelines. Additional strategies are needed to improve the detection and prevention of EOCRC for individuals not meeting family history criteria for early screening.

Keyphrases

early onset
late onset
clinical practice
tyrosine kinase
loop mediated isothermal amplification
label free