Synthesis of Chalcones, Screening In silico and In vitro and Evaluation of Helicobacter pylori Adhesion by Molecular Docking.
Rodrigo de Almeida RomagnaReginaldo Bezerra Dos SantosRita de Cassia Ribeiro GonçalvesRodrigo Rezende KitagawaPublished in: Current pharmaceutical design (2024)
All compounds exhibited strong activity against H. pylori, specially 15. The predicted MMP-9 inhibition by molecular docking added to the reasonable SI and CI50 values for 15 and the satisfactory reduction in the rate of survival of the bacteria, reveals that it may be acting synergically to reduce the inflammatory response and the possibilities for developing a tumor by inhibiting both bacteria and malignant cells.
Keyphrases
- molecular docking
- helicobacter pylori
- inflammatory response
- induced apoptosis
- molecular dynamics simulations
- helicobacter pylori infection
- cell cycle arrest
- signaling pathway
- cell migration
- lipopolysaccharide induced
- lps induced
- endoplasmic reticulum stress
- oxidative stress
- cell death
- biofilm formation
- room temperature
- staphylococcus aureus
- pseudomonas aeruginosa
- cell proliferation