Investigating the relationship between melatonin patterns and methylation in circadian genes among day shift and night shift workers.

Jennifer A RitonjaKristan J AronsonMichael LeungLisa FlatenDanai Georgia TopouzaQing Ling DuanFrancine DurocherJoan E TranmerParveen Bhatti

Published in: Occupational and environmental medicine (2022)

In conclusion, patterns in melatonin secretion were associated with differential circadian gene methylation among night shift workers. Melatonin and alteration of DNA methylation in circadian genes may be one pathway towards increased cancer risk, although larger-scale studies examining multiple time points are needed.

Keyphrases

genome wide
dna methylation
copy number
genome wide identification
gene expression
sleep quality
genome wide analysis
bioinformatics analysis
physical activity