Hepatoprotective Effects of Hyaluronic Acid-Preconditioned Bone Marrow Mesenchymal Stem Cells against Liver Toxicity via the Inhibition of Apoptosis and the Wnt/β-Catenin Signaling Pathway.
Amira AwadallaEman T HamamSally Abdallah MostafaSeham Ahmed MahmoudKhalid Mohamed ElazabAhmed Mohamed El NakibMamdouh EldesoquiMohamed El SherbinyOmar A AmmarRasha Hamed Al-SerwiMohamed A SalehAmira SarhanMohamed AliPublished in: Cells (2023)
Our findings proved that BMSCs treated with HA exert their paracrine therapeutic effects via their secretome, suggesting that cell-based regenerative therapies conditioned with HA may be a viable alternative to reduce hepatotoxicity.