Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity.

Ruochuan ZangXinfeng WangRunsen JinYuanyuan LeiJianbing HuangChengming LiuSufei ZhengFang ZhouQian WuNan SunShugeng GaoJie He

Published in: Journal of translational medicine (2019)

The combination of single biomarkers with high stage-specificity and histological type specificity (SHOX2 and PTGER4 DNA methylation and IDH1) showed better diagnostic performance in the detection of lung cancers compared with single marker assessment. A greater clinical utility of the panel may be developed by adding demographic/epidemiologic characteristics.

Keyphrases

dna methylation
genome wide
gene expression
low grade
structural basis
copy number
high grade
young adults
label free
childhood cancer