A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Kayode OgungbenroJonathan B WagnerSusan Abdel-RahmanJ Steven LeederAleksandra GaletinPublished in: European journal of clinical pharmacology (2019)
The model developed describes the pharmacokinetics of simvastatin and its metabolites in children/adolescents capturing the effects of both c.521T>C and age on variability in exposure in this patient population. This joint simvastatin metabolite model is envisaged to facilitate optimisation of simvastatin dosing in children/adolescents.