Removal of doravirine by haemodialysis in people living with HIV with end-stage renal disease.
José MoltóFredzzia GraterolAdrian CurranNatalia RamosArkaitz ImazDiego SandovalFrancisco PérezLucía BailónSaye KhooLaura ElseRoger ParedesPublished in: The Journal of antimicrobial chemotherapy (2022)
Despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.