The nonredundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway.
Ana R MoshkovskyMarc W KirschnerPublished in: Proceedings of the National Academy of Sciences of the United States of America (2022)
Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of β-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the transcriptional and proteostatic level confers differential responsiveness that can be used in tissue-specific regulation. Such subtle features may distinguish other redundant gene pairs that are commonly found in vertebrates through gene knockout experiments.
Keyphrases
- genome wide
- genome wide identification
- signaling pathway
- cell proliferation
- copy number
- transcription factor
- stem cells
- epithelial mesenchymal transition
- dna methylation
- genome wide analysis
- gene expression
- small molecule
- induced apoptosis
- amino acid
- oxidative stress
- protein protein
- heat stress
- endoplasmic reticulum stress
- network analysis
- wild type
- heat shock protein