Detecting Somatic Mutations for Well-Differentiated Pancreatic Neuroendocrine Tumors in Endoscopic Ultrasound-Guided Fine Needle Aspiration with Next-Generation Sequencing.

Elie M GhabiJoseph R HabibSami ShoucairAmmar A JavedJonathan ShamWilliam R BurnsJohn L CameronSyed Z AliEun Ji ShinPaolo Giorgio ArcidiaconoClaudio DoglioniMassimo FalconiJun YuStefano PartelliJin He

Published in: Annals of surgical oncology (2023)

NGS can detect somatic mutations in EUS-FNA specimens of well-differentiated PanNETs. Efforts to improve detection sensitivity and mutational concordance are required to overcome current technical limitations.

Keyphrases

fine needle aspiration
ultrasound guided
neuroendocrine tumors
copy number
label free
genome wide
dna methylation
real time pcr
gene expression
circulating tumor cells