Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis.

Kristina Elizabeth Neergaard ClarkCorrado CampochiaroEszter CsomorAdam TaylorKatherine NevinNicholas GalweyMary A MorseJennifer SinghYee Voan TeoVoon H OngEmma Derrett-SmithNicolas WisniackiShaun M FlintChristopher P Denton

Published in: Annals of the rheumatic diseases (2021)

Our findings provide insight into clinical diversity and imply pathogenetic differences between ANA-based subgroups. This supports stratification of SSc cases by ANA antibody subtype in clinical trials and may explain different outcomes across ANA subgroups in trials targeting specific pathogenic mechanisms.

Keyphrases

systemic sclerosis
clinical trial
interstitial lung disease
type diabetes
rheumatoid arthritis
low grade
cancer therapy
adipose tissue
high grade
idiopathic pulmonary fibrosis