Outcomes of Patients with Normal LDL-Cholesterol at Admission for Acute Coronary Syndromes: Lower Is Not Always Better.
Ivana JurinAnđela JurišićIgor RudežEna KurtićIvan SkorićTomislav ČikaraTomislav ŠipićDiana RudanŠime ManolaIrzal HadžibegovićPublished in: Journal of cardiovascular development and disease (2024)
A spontaneously normal LDL-C level at admission for ACS in statin-naïve patients was not rare and it was an independent risk factor for both substantially higher in-hospital mortality and mortality during long-term follow-up. Patients with normal LDL-C and otherwise high total cardiovascular risk scores should be detected early and treated with optimal medical therapy. However, additional research is needed to reveal all the missing pieces in their survival puzzle after ACS-beyond coronary anatomy, PCI optimization, numerical LDL-C levels, and statin therapy.
Keyphrases
- low density lipoprotein
- acute coronary syndrome
- coronary artery disease
- end stage renal disease
- percutaneous coronary intervention
- antiplatelet therapy
- newly diagnosed
- emergency department
- ejection fraction
- cardiovascular disease
- chronic kidney disease
- cardiovascular events
- coronary artery
- peritoneal dialysis
- healthcare
- prognostic factors
- genome wide
- gene expression
- patient reported outcomes
- type diabetes
- aortic stenosis
- left ventricular
- coronary artery bypass grafting
- risk factors
- single cell
- bone marrow
- weight loss
- free survival
- replacement therapy
- insulin resistance