Targeting Mitochondrial Complex I Deficiency in MPP + /MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene.

Hongzhi LiJing ZhangYuqi ShenYifan YeQingyou JiangLan ChenBohao SunZhuo ChenLuxi ShenHezhi FangJifeng YangHaihua Gu

Published in: Biological procedures online (2024)

/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.

Keyphrases

high glucose
diabetic rats
gene therapy
mouse model
drug induced
oxidative stress
endothelial cells
spinal cord
gene expression
copy number
genome wide
transcription factor
cancer therapy
drug delivery
replacement therapy