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The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis.

Kaige YangRongli XieGuohui XiaoZhifeng ZhaoMin DingTingyu LinYiu Sing TsangYing ChenDan XuJian Fei
Published in: Journal of translational medicine (2024)
We deciphered the distinct roadmap of acinar cells in the early stage of AP at single-cell level. ERS and ERAD pathways are crucially important for acinar homeostasis and the pathogenesis of AP.
Keyphrases
  • single cell
  • rna seq
  • early stage
  • induced apoptosis
  • transcription factor
  • high throughput
  • cell cycle arrest
  • oxidative stress
  • radiation therapy
  • bone marrow
  • cell proliferation
  • lymph node
  • cell therapy