Treatment with an Inhibitor of Matrix Metalloproteinase 9 or Cathepsin K Lengthens Embryonic Lower Jaw Bone.
Claire J HouchenBethany CastroPortia Hahn LeatNashwa MohammadFaith Hall-GlennErin Ealba BumannPublished in: Orthodontics & craniofacial research (2023)
MMP9 and CTSK play a role in osteoclast-mediated determination of lower jaw bone length. Pharmacological inhibition of MMP9 or CTSK may be a promising therapeutic alternative to surgery for treating skeletal jaw malocclusions, but more preclinical research is needed prior to clinical translation.
Keyphrases
- bone loss
- bone mineral density
- minimally invasive
- soft tissue
- cell migration
- coronary artery bypass
- bone regeneration
- solid phase extraction
- stem cells
- molecularly imprinted
- surgical site infection
- combination therapy
- mass spectrometry
- bone marrow
- acute coronary syndrome
- percutaneous coronary intervention
- smoking cessation