LC-MS metabolomics analysis of serum metabolites during neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

Qiliang PengLili JiangYi ShenYao XuXinan ShenLi ZouYa-Qun ZhuYuntian Shen

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)

This study demonstrated the potential of LC-MS metabolomics for revealing the serum metabolite profiles during NCRT in LARC. The identified metabolites may serve as potential biomarkers and therapeutic targets for the management of this disease. Furthermore, the understanding of the affected metabolic pathways may help design more personalized therapeutic strategies for LARC patients.

Keyphrases

rectal cancer
locally advanced
neoadjuvant chemotherapy
squamous cell carcinoma
phase ii study
mass spectrometry
radiation therapy
ms ms
ejection fraction
end stage renal disease
newly diagnosed
prognostic factors
clinical trial
study protocol